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Symbol: Gclm Name: Glutamate-cysteine ligase modifier subunit Entrez gene ID: 248194 Ensembl gene ID: FBgn0046114 Species: Fly (Taxid: 7227) Functional description: Glutamate-cysteine ligase modifier subunit; Glutamate-cysteine ligase modifier subunit [Source:FlyBase gene name;Acc:FBgn0046114] [Ensembl]; The gene Glutamate-cysteine ligase modifier subunit is referred to in FlyBase by the symbol Dmel\Gclm (CG4919, FBgn0046114). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: glutamate-cysteine ligase catalytic subunit binding; enzyme binding; enzyme regulator activity. There is experimental evidence that it is involved in the biological process: olfactory learning; learning or memory; glutathione biosynthetic process; response to DNA damage stimulus; long-term memory; positive regulation of glutamate-cysteine ligase activity. 13 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: NADP-dependent oxidoreductase domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, during early larval stages, in adult female stages. [FlyBase] Observation: Overexpression of Gclm extends the mean lifespan by up to 24% [16148000]. Interventions: Assays: Organismal Lifespan Mean: +24 Classification: Type: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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