|
Symbol: Gclc Name: Glutamate-cysteine ligase catalytic subunit Entrez gene ID: 53581 Ensembl gene ID: FBgn0040319 Species: Fly (Taxid: 7227) Functional description: Glutamate-cysteine ligase catalytic subunit; Glutamate-cysteine ligase catalytic subunit [Source:FlyBase gene name;Acc:FBgn0040319] [Ensembl]; The gene Glutamate-cysteine ligase catalytic subunit is referred to in FlyBase by the symbol Dmel\Gclc (CG2259, FBgn0040319). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: glutamate-cysteine ligase activity; protein binding. There is experimental evidence that it is involved in the biological process: glutathione biosynthetic process; response to DNA damage stimulus; glutathione metabolic process. 8 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Glutamate-cysteine ligase catalytic subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages. [FlyBase] Observation: Overexpression of Gclc extends mean and maximum lifespan by up to 50% [16148000]. Interventions: Assays: Organismal Lifespan Mean: +50 Maximum: +50 Classification: Type: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Inparanoids Edit \ Update (Admin) | Delete |
Comment on This Data Unit