Denigma: Factor

Fxn

Symbol: Fxn
Name: frataxin
Entrez gene ID: 14297
Ensembl gene ID: ENSMUSG00000059363
Species: Mouse (Taxid: 10090)

Functional description:
Regulation of mitochondrial iron transport and respiration; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). [UniProt]

Observation:

Disruption results in reduced lifespan, increased oxidative stress, impaired respiration, and the development of hepatic tumors [16278235].

Interventions:

Fxn disruption

Assays: Organismal Lifespan

Classification:

Aging-Suppressor

Negative Aging-Suppressor

Cancer-Related

Tumor-Suppressor

References:

16278235: Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.

Aging Relevance Analysis/Source:

GenAge