Fwd

Symbol: Fwd
Name: four wheel drive
Entrez gene ID: 45374
Ensembl gene ID: FBgn0004373
Species: Fly (Taxid: 7227)

Functional description:
four wheel drive; four wheel drive [Source:FlyBase gene name;Acc:FBgn0004373] [Ensembl]; The gene four wheel drive is referred to in FlyBase by the symbol Dmel\fwd (CG7004, FBgn0004373). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: 1-phosphatidylinositol 4-kinase activity. There is experimental evidence that it is involved in the biological process: male meiosis cytokinesis; contractile ring contraction involved in cell cycle cytokinesis; male germline ring canal formation; determination of adult lifespan; meiotic spindle stabilization; cytokinesis after meiosis II; spermatocyte division; spermatogenesis; cytokinesis after meiosis I. 24 alleles are reported. The phenotypes of these alleles are annotated with: secondary spermatocyte; Nebenkern; Nebenkern derivative; spermatid; spermatid axoneme; spermatozoon. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Phosphatidylinositol 3-/4-kinase, catalytic domain; Phosphatidylinositol 3/4-kinase, conserved site; Phosphatidylinositol Kinase; Protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [FlyBase]

Observation:

Overexpression of Fwd (from a doxycline-inducible promoter) increases mean lifespan by 7-9% [12620118]. Fwd regulates actin organization and ring canal formation during germline cytokinesis [10934029] by catalysing the first step in the synthesis of the key regulatory membrane phsopholipid PIP2, which is generated from PIP by a PI 4,5-kinase.



Interventions:
  • Fwd overexpression +7 to +9%

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PI4KB (9606)
  • PI4KB (9598)
  • PI4KB (9615)
  • PI4KB (9913)
  • Pi4kb (10090)
  • Pi4kb (10116)
  • PI4KB (9031)
  • pi4kb (7955)
  • fwd (7227)
  • AgaP_AGAP007512 (7165)
  • F35H12.4 (6239)



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