Denigma: Factor

frh-1

Symbol: frh-1
Name: FRataxin (involved in human Friedrich's ataxia) Homolog
Entrez gene ID: 174002
Ensembl gene ID: F59G1.7
Species: Worm (Taxid: 6239)

Functional description:
Regulation of mitochondrial iron transport and respiration; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. [UniProt]

Observation:

Inactivation by RNA interference resulted in small body size, reduced fertility, altered responses to oxidative stress and life-extension.

Assays:

Classification:

Aging Relevance Analysis/Source:

GenAge