Denigma

nhr-62

Symbol: nhr-62
Name: Nuclear Hormone Receptor family
Entrez gene ID: 172836
Species: Worm (Taxid: 6239)


Observation:

NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity response of eat-2 mutants and blunts the longevity by bacterial food dilution [Heestand, et al. 2012].

Mutation in nhr-62 suppresses the lifespan extension of eat-2(ad465) animals (p<0.001) [Heestand et al. 2013].

Wild-type (N2) worms with extrachromosomal array dhEx627 (carrying a wild-type nhr-62) exhibit a significant increase in lifespan compared to wild-type (p<0.001) [Heestand et al. 2013].



Interventions:
  • nhr-62 Overexpression
  • nhr-62 Mutation

    • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • DR-Essential


    • Type:
  • Gene
  • Protein coding

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • nhr-21 (6239)
  • nhr-4 (6239)
  • nhr-62 (6239)
  • nhr-34 (6239)
  • nhr-138 (6239)
  • nhr-118 (6239)
  • nhr-100 (6239)
  • nhr-46 (6239)
  • nhr-61 (6239)



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