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Symbol: atp-3 Name: ATP synthase subunit Entrez gene ID: 172195 Ensembl gene ID: F27C1.7 Species: Worm (Taxid: 6239) Functional description: Mitochondrial F1F0-ATP synthase, subunit OSCP/ATP5; Protein ATP-3; ATP synthase subunit family member (atp-3) [Source:RefSeq peptide;Acc:NP_001021421] [Ensembl]; atp-3 encodes the C. elegans homolog of the ATP5O subunit of mitochondrial ATP synthase (complex V); as part of the ATP synthase complex, ATP-3 controls respiration and regulates growth rate and body size, aging, and rates of behaviors such as pharyngeal pumping, defecation, and locomotion; loss of atp-3 function during larval development indicates that respiratory rates established during development persist into adulthood. [WormBase] Observation: RNA interference against atp-3 results in lifespan extension [16103914]. atp-3 RNAi increases lifespan by 46% (mean by 33 and maximum by 70%). RNAi of atp-3 during larval stage is necessary and sufficient for lifespan prologation, while atp-3 RNAi only during the adulthood fails the extend lifespan. atp-3 RNAi results in reduced pharageal pumping, defection and motility as well as ATP levels and body size [12471266]. Interventions: Assays: Organismal Lifespan Mean: +33 Maximum: +70 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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