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Symbol: F28D1.9 Entrez gene ID: 178190 Ensembl gene ID: F28D1.9 Species: Worm (Taxid: 6239) Functional description: Fatty acid transporter; Protein ACS-20; Protein ACS-20 [Source:UniProtKB/TrEMBL;Acc:Q19878] [Ensembl]; acs-20 encodes a protein homologous to the mammalian FATP1 and FATP4 fatty acid transport proteins (FATP)/very long chain fatty acid acyl-CoA synthetases; acs-20 activity is required for proper cuticle development, specifically formation of a cuticle surface barrier that prevents penetration of small molecules; acs-20 may affect cuticle development via its role in incorporation of very long chain fatty acids, but not other fatty acids, into sphingomyelin; acs-20; acs-22 doubly mutant animals have more severe cuticle barrier defects than acs-20 single mutants, suggesting that the two genes function redundantly; acs-20 defects can be rescued by human Fatp4; an ACS-20::GFP fusion protein is expressed in the hyp7 and seam hypodermis, as well as the vulval and anal muscles; in hypodermal cells, ACS-20 localizes in a reticular pattern suggestive of localization to the endoplasmic reticulum. [WormBase] Observation: RNA interference decreased median lifespan by 50% in wild type animals and 70% in daf-2 mutants. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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