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Symbol: set-9 Name: SET (trithorax/polycomb) domain containing 9 Entrez gene ID: 177196 Ensembl gene ID: F15E6.1 Species: Worm (Taxid: 6239) Functional description: Protein SET-9; SET (trithorax/polycomb) domain containing family member (set-9) [Source:RefSeq peptide;Acc:NP_500539] [Ensembl]; set-9 encodes a large (1,655-residue) protein with a low-complexity N-terminal region, followed by a PHD-zinc finger and a SET domain; SET-9 has no non-nematode orthologs, but has 96% identity (1616/1679 residues) to its paralog SET-26; SET-9 is required for a normally short lifespan and low spontaneous mutation rate; life extension by set-9(RNAi) requires DAF-16, indicating that SET-9 limits normal lifespan by negatively regulating DAF-16 (either directly or indirectly); otherwise, neither set-9(n4949) nor set-9(RNAi) have any obvious phenotypes. [WormBase] Observation: RNA interference of set-9 extends lifespan [15998808]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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