TNF

Symbol: TNF
Name: tumor necrosis factor
Entrez gene ID: 7124
Ensembl gene ID: ENSG00000232810
Species: Human (Taxid: 9606)


Observation:

The frequency of the -308 polymorphism in the TNF gene was analyzed in 71 healthy elders, aged 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The TNF2 allele was increased in the elder group when compared to young controls [16269080].TNF was found to be associated with longevity [20518833]. TNF was found to be associated with longevity [18511747]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12676903]. TNF was found to be associated with longevity [11640949]. TNF was found to be associated with longevity [21299522]. TNF was found to be associated with longevity [21299522]. TNF was not found to be associated with longevity [12676903]. TNF was found to be associated with longevity [16269080]. TNF was not found to be associated with longevity [11640949].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs1800629 1.0 [20518833]
  • rs1800629 0.019 [18511747]
  • rs1800629 1.0 [12714268]
  • rs909253 1.0 [12714268]
  • TNF haplotypes 0.01 [21299522]
  • rs1800629 1.0 [12676903]
  • rs1800629 0.76 [11640949]
  • -308G/A 0.001 [16269080]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene
  • Protein coding

    References:
  • 16269080: Human leukocyte antigen class I, class II, and tumor necrosis factor-alpha polymorphisms in a healthy elder Mexican Mestizo population.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • TNF (9606)
  • TNF (9598)
  • TNF (9615)
  • TNF (9913)
  • Tnf (10090)
  • Tnf (10116)



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