4 SNPs (-800 G/A, -509 C/T, +869 T/C and +915 G/C) in the TGFB1 gene were analysed in 419 subjects from Northern and Central Italy, including 172 centenarians and 247 younger controls. Significant differences were found at the +915 site as far as the C allele and GC genotype were concerned, both of them being lower in centenarians than in young controls, but none of the other tested genetic variants was significantly different between centenarians and controls. Moreover, a particular haplotype combination (G -800/C -509/C 869/C 915) was notably lower in centenarians than in younger individuals [15569360].TGFB1 was found to be associated with longevity [21299522]. TGFB1 was found to be associated with longevity [21299522]. TGFB1 was found to be associated with longevity [15569360].

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