SLC6A4

Symbol: SLC6A4
Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Entrez gene ID: 6532
Ensembl gene ID: ENSG00000108576
Species: Human (Taxid: 9606)


Observation:

Two alleles, 44-bp insertion (l allele) or deletion (s allele) in the promoter region of SLC6A4, were examined in 265 Japanese centenarians and control subjects. The frequency of the l/l genotype and the l allele was significantly greater in centenarians than in younger control subjects, particularly women [16095668].SLC6A4 was found to be associated with longevity [22985157].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • 5-HTTLPR 0.03 [22985157]

  • Classification:
  • Longevity-Associated


  • Type:
  • Gene
  • Protein coding

    References:
  • 16095668: Contribution of an affect-associated gene to human longevity: prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SLC6A4 (9606)
  • SLC6A4 (9598)
  • SLC6A4 (9615)
  • SLC6A4 (9913)
  • Slc6a4 (10090)
  • Slc6a4 (10116)
  • SLC6A4 (9031)
  • slc6a4a (7955)



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