Denigma

PON1

Symbol: PON1
Name: paraoxonase 1
Entrez gene ID: 5444
Ensembl gene ID: ENSG00000005421
Species: Human (Taxid: 9606)


Observation:

Polymorphism at codon 192 (Gln/Arg) of the PON1 gene was examined in 256 healthy Caucasian men (69.8 +/- 4.0 years). Gln homozygotes are more frequent in aging than Arg allele carriers [12889841].PON1 was found to be associated with longevity [15050299]. PON1 was found to be associated with longevity [15050299]. PON1 was found to be associated with longevity [17903295]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [16799134]. PON1 was found to be associated with longevity [16799134]. PON1 was found to be associated with longevity [15050299]. PON1 was not found to be associated with longevity [15241482]. PON1 was found to be associated with longevity [15241482]. PON1 was not found to be associated with longevity [20362697]. PON1 was not found to be associated with longevity [18034366].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • 55 (L/M) 0.44 [15050299]
  • 192 (Q/R) 0.007 [15050299]
  • rs662 1.0 [12082503]
  • rs854560 1.0 [12082503]
  • 192/55 loci 0.01 [12082503]
  • codon 192 1.0 [16799134]
  • codon 55 1.0 [16799134]
  • 192 0.007 [15050299]
  • rs854560 None [15241482]
  • rs662 None [18034366]

    • Classification:
  • Longevity-Associated
  • No Age Effect


    • Type:
  • Gene
  • Protein coding

    References:
  • 12889841: Effect of six candidate genes on early aging in a French population.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • PON1 (9606)
  • PON1 (9598)
  • PON1 (9615)
  • PON1 (9913)
  • Pon1 (10090)
  • Pon1 (10116)

    • Inparanoids
  • ENSMUSP00000002663 (10090)
  • ENSRNOP00000011823 (10116)
  • ENSMMUP00000010502 (9544)



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