IFNG

Symbol: IFNG
Name: interferon, gamma
Entrez gene ID: 3458
Ensembl gene ID: ENSG00000111537
Species: Human (Taxid: 9606)


Observation:

The distribution of 874T/A polymorphism in the IFNG gene was examined in 174 Italian centenarians (>99 years old, 142 women and 32 men) and 248 <60-year-old control subjects (90 women and 158 men). The +874T allele, known to be associated with low IFN-gamma production, was found less frequently in centenarian women than in centenarian men or in control women whereas no significant differences were observed in the distribution of the two alleles between male or female controls. Allele frequencies in centenarian men were not found significantly different from male controls [11772518].IFNG was found to be associated with longevity [21299522]. IFNG was not found to be associated with longevity [11772518]. IFNG was found to be associated with longevity [11772518].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • Not specified 0.05 [21299522]
  • rs2430561 0.02 [11772518]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene
  • Protein coding

    References:
  • 11772518: Allele frequencies of +874T--&gt;A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • IFNG (9606)
  • IFNG (9598)
  • IFNG (9615)
  • IFNG (9913)
  • Ifng (10090)
  • Ifng (10116)

  • Inparanoids
  • ENSMUSP00000063800 (10090)
  • ENSRNOP00000009917 (10116)
  • ENSMMUP00000025266 (9544)



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