Denigma: Factor

F08B4.7

Symbol: F08B4.7
Entrez gene ID: 177674
Ensembl gene ID: F08B4.7
Species: Worm (Taxid: 6239)

Functional description:
Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity). [UniProt]

Observation:

RNA interference increased mean lifespan by 21%.

Assays:

Classification:

Aging Relevance Analysis/Source:

GenAge