TLR4

Symbol: TLR4
Name: toll-like receptor 4
Entrez gene ID: 7099
Ensembl gene ID: ENSG00000136869
Species: Human (Taxid: 9606)


Observation:

The ASP299GLY ploymorphism in the TLR4 gene shows a significantly lower frequency in patients affected by myocardial infarction compared to controls, whereas centenarians exhibit a higher frequency [16803999]. TLR4 was found to be associated with longevity [16803999; 17493663].TLR4 was found to be associated with longevity [17493663]. TLR4 was not found to be associated with longevity [17493663].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs4986790 0.61 [17493663]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene

    References:
  • 16803999: Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4.
  • 17493663: Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • TLR4 (9606)
  • TLR4 (9598)
  • TLR4 (9913)
  • Tlr4 (10090)
  • Tlr4 (10116)
  • TLR4 (9031)
  • LOC795671 (7955)
  • tlr4ba (7955)
  • tlr4bb (7955)

  • Inparanoids
  • ENSMUSP00000045770 (10090)
  • ENSRNOP00000014020 (10116)
  • ENSMMUP00000039787 (9544)



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