Denigma: Factor

mrps-5

Symbol: mrps-5
Entrez gene ID: 179721
Species: Worm (Taxid: 6239)

Observation:

Knockdown of mrps-5 throughout the entire life increases the lifespan by 60%. mrps-5 RNAi prevents aging-associated functional decline and alters mitochondrial function. Knocking down mrps-5 after early development no longer affects nematode lifespan. When RNAi of mrps-5 was performed during the larval stages only, lifespan increases by 48%, whereas RNAi started from the L4 stage has no effect. mrps-5 RNAi results in fragmented mitochondria. mrps-5 RNAi increases lifespan by 40% in widltype, 37% in daf-16(mu86), 40% in sir-2.1(ok434) 69% in aak-2(ok524) and 112% in mev-1(kn1). Knockdown of cco-1 does not extend the lifespan of mrps-5 RNAi [23698443].

Interventions:

mrps-5 RNAi +60%

Assays: Organismal Lifespan
Mean: +60

Classification:

Gerontogene

Positive Gerontogene

Type:

Gene

Protein coding

References:

23698443: Mitonuclear protein imbalance as a conserved longevity mechanism.

Aging Relevance Analysis/Source:

GenAge