|
Symbol: ero-1 Name: Endoplasmic Reticulum Oxidase Entrez gene ID: 173325 Ensembl gene ID: Y105E8B.8 Species: Worm (Taxid: 6239) Functional description: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly pdi-1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on pdi-1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between pdi-1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress (By similarity). [UniProt] Observation: RNA interference in adulthood resulted in a 32% mean lifespan extension. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit