Hsp70Ba

Symbol: Hsp70Ba
Name: Heat-shock-protein-70Ba
Entrez gene ID: 44921
Ensembl gene ID: FBgn0013277
Species: Fly (Taxid: 7227)


Observation:

Hsp70Ba overexpression reduces mean and maximum lifespan up to 30% [19420297].

hsp70 and hsp22 RNA levels are higher in long-lived than in short-lived fly lines. The HDAC inhibitor TSA causes a higher expression of hsp22 and hsp70, and strikingly influences the lifespan in both long and short-lived lines, with variable degrees (up to 25%) [15695762].



Interventions:
  • Trichostatin A supplementation +25%
  • Hsp70Ba overexpression -30% -30%

  • Assays: Chronological Lifespan
    Mean: -30
    Maximum: -30

    Classification:
  • Longevity-Associated
  • Longevity-Induced


  • Type:
  • Gene
  • Protein coding

    References:
  • 19420297: Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions.
  • 15695762: Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HSPA1A (9606)
  • HSPA1B (9606)
  • HSP70 (9615)
  • HSPA1A (9913)
  • Hspa1b (10090)
  • Hspa1a (10090)
  • Hspa1b (10116)
  • LOC100333726 (7955)
  • Hsp70Ab (7227)
  • Hsp68 (7227)
  • Hsp70Aa (7227)
  • Hsp70Bc (7227)
  • Hsp70Ba (7227)
  • Hsp70Bb (7227)
  • Hsp70Bbb (7227)
  • SSA3 (4932)
  • KLLA0E20527g (28985)
  • AGOS_AER187W (33169)
  • AT3G09440 (3702)



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