Nlaz

Symbol: Nlaz
Name: Neural Lazarillo
Entrez gene ID: 33324
Ensembl gene ID: FBgn0053126
Species: Fly (Taxid: 7227)


Observation:

Absence of Nlaz, which is homologous to ApoD, results in a reduced lifespan in both sexes. Median lifespan is 30.8% and 22.5% lower in females and males, respectively. Maximum lifespan is reduced by 12% and 30% in females and males [21376794].



Interventions:
  • Nlaz mutation -22.5 to -30.8% -12 to -30%

  • Assays: Organismal Lifespan
    Median: -22.5 to -30.8
    Maximum: -12 to -30

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Type:
  • Gene
  • Protein coding

    References:
  • 21376794: Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • APOD (9606)
  • APOD (9598)
  • APOD (9615)
  • APOD (9913)
  • Apod (10090)
  • Apod (10116)
  • APOD (9031)
  • zgc:123339 (7955)
  • zgc:153593 (7955)
  • NLaz (7227)
  • AgaP_AGAP009281 (7165)

  • Inparanoids
  • ENSMUSP00000023207 (10090)
  • ENSMMUP00000038233 (9544)
  • ENSP00000345179 (9606)



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