Denigma

Naam

Symbol: Naam
Name: Nicotinamide amidase
Entrez gene ID: 42348
Ensembl gene ID: FBgn0051216
Species: Fly (Taxid: 7227)


Observation:

Naam overexpression increases mean and maximum lifespan by 30% in both females and males. The lifespan extension is reversed by Sir2 mutants, indicating the it is dependent on Sir2 [18678867].



Interventions:
  • Naam overexpression +30% +30%

    • Assays: Organismal Lifespan
    Mean: +30
    Maximum: +30

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


    • Type:
  • Gene
  • Protein coding

    References:
  • 18678867: Life span extension and neuronal cell protection by Drosophila nicotinamidase.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • CG31216 (7227)
  • AgaP_AGAP001435 (7165)
  • pnc-2 (6239)
  • pnc-1 (6239)
  • SPBC365.20c (4896)
  • PNC1 (4932)
  • KLLA0F22242g (28985)
  • AGOS_AFR466C (33169)
  • GeneID:2679961 (148305)
  • NCU00713 (5141)

    • Orthologs
  • PNC1 (4932)
  • PNC1 (4932)
  • PNC1 (4932)

    • Inparanoids
  • FBpp0083200 (7227)
  • YGL037C (4932)
  • SPBC365.20c (4896)



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