Denigma

LBR

Symbol: LBR
Name: Lamin B receptor
Entrez gene ID: 37482
Ensembl gene ID: FBgn0034657
Species: Fly (Taxid: 7227)


Observation:

Overexpression of Lamin B receptor in the adult muscle and in the abdominal fat body results in a 54% and 46% reduction of mean lifespan, respectively [18494863].



Interventions:
  • LBR overexpression

    • Assays: Organismal Lifespan
    Mean: -46 to -54

    Classification:
  • Gerontogene
  • Negative Gerontogene


    • Type:
  • Gene
  • Protein coding

    References:
  • 18494863: The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • LBR (7227)
  • AgaP_AGAP003745 (7165)

    • Inparanoids
  • ENSMUSP00000005003 (10090)
  • ENSRNOP00000031360 (10116)
  • ENSMMUP00000004630 (9544)
  • ENSP00000339883 (9606)
  • SPBC16G5.18 (4896)



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