CG3776

Symbol: CG3776
Alias: Dmel\CG3776; DmP29; EP(2)0835; Jhebp29; P29
Entrez gene ID: 37996
Ensembl gene ID: FBgn0035088
Species: Fly (Taxid: 7227)


Observation:

Both overexpression and underexpression of CG3776 (alias Jhebp29) reduces the mean lifespan, where the reduction in males is slightly higher.

The lifespan of male flies with under- and overexpressed CG3776 is reduced by 38.8 and 42.6%, respectively when compared with Oregon R flies.The lifespan of female flies with under- and overexpressed CG3776 is reduced by 31.6 and 35%, respectively when compared to Oregon R flies.

Among the males and females, relatively to Oregon R and EP835/CyO, the age-specific survival of EP835/EP835 and EP835/Gal4 is reduced in both log-rank and Wilcoxon tests (P < 0.001); survival of EP835/EP835 and EP835/Gal4 differed using the log-rank-test (male: P<0.001; female: P=0.027) [18275960].



Interventions:
  • CG3776 overexpression -35 to -42.6%
  • CG3776 underexpression -31.6 to -38.8%

  • Assays: Organismal Lifespan
    Mean: -31.6 to -42.6

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Gerontogene
  • Negative Gerontogene


  • Type:
  • Gene
  • Protein coding

    References:
  • 18275960: Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • Jhebp29 (7227)
  • AgaP_AGAP009891 (7165)

  • Inparanoids
  • FBpp0072302 (7227)
  • ENSMUSP00000027114 (10090)
  • ENSRNOP00000021533 (10116)
  • ENSMMUP00000030495 (9544)
  • ENSP00000295079 (9606)

  • Note: Does it require a new category of lifespan factor? How is CG3776 underexpressed. Define the type of intervention.

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