Denigma: Factor

E(z)

Symbol: E(z)
Name: Enhancer of zeste
Entrez gene ID: 39203
Ensembl gene ID: FBgn0000629
Species: Fly (Taxid: 7227)

Observation:

Flies heterozygous for the protein null E(z)63 or the catalytically inactive E(z)731 mutation that are progeny of an out-cross to an Oregon-R (O-R) wild-type strain exhibit a substantially greater median lifespan than the O-R control (71% and 76%, respectively). When derived from an out-cross to a longer-lived Canton-S (C-S) wild-type strain, the median lifespan of E(z)63 heterozygous is 33% longer than the C-S control [20018689].

Assays: Organismal Lifespan
Median: +33 to +76

Classification:

Gerontogene

Positive Gerontogene

Type:

Gene

Protein coding

References:

20018689: Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.

Aging Relevance Analysis/Source:

GenAge