Denigma: Factor

alpha-Man-I

Symbol: alpha-Man-I
Name: alpha Mannosidase I
Entrez gene ID: 31957
Ensembl gene ID: FBgn0259170
Species: Fly (Taxid: 7227)

Observation:

alpha-Man-I mutant fly exhibit enhanced resistance to paraquat and starvation an a 60% increase in mean lifespan for both sexes. After outcrossing, the mutant exhibit, under normal conditions, an increase in mean lifespan of 22% for females and 38% for males. Maximum lifespan is increased by 15%. alpha-Man-I RNAi knockdown results in a 39% increase in mean lifespan [19302370].

Interventions:

alpha-Man-I mutation +22 to +60% +15%

alpha-Man-I RNAi +39%

Assays: Organismal Lifespan
Mean: +22 to 60
Maximum: +15

Classification:

Gerontogene

Positive Gerontogene

Type:

Gene

Protein coding

References:

19302370: Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans.

Aging Relevance Analysis/Source:

GenAge