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Symbol: Atg8a Name: Autophagy-related 8a Entrez gene ID: 32001 Ensembl gene ID: FBgn0052672 Species: Fly (Taxid: 7227) Functional description: Involved in autophagy; Autophagy-specific gene 8a; Autophagy-specific gene 8a [Source:FlyBase gene name;Acc:FBgn0052672] [Ensembl]; The gene Autophagy-specific gene 8a is referred to in FlyBase by the symbol Dmel\Atg8a (CG32672, FBgn0052672). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: regulation of protein ubiquitination; determination of adult lifespan; macroautophagy. 18 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval salivary gland. It has one annotated transcript and one annotated polypeptide. Protein features are: Autophagy protein Atg8 ubiquitin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [FlyBase] Observation: Mutations in Atg8a results in reduced lifespan and increased sensitivity to oxidative stress while enhanced expression in older fly brains extends average adult lifespan by 56% and promotes resistance to oxidative stress [18059160]. Atg8a mutation reduces the maximum lifespan by 25% under starvation conditions [17617737]. Loss-of-function mutation in Atg8a reduces mean lifespan by 11 - 25% and maximum lifespan by 3 - 22% [17435236]. Interventions: Assays: Organismal Lifespan Mean: -25 to +56 Maximum: -3 to -25 Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Note: GenAge reports also another reference [19550147] which does not appear to have any data on Atg8a, right? Is the lifespan reduction only under starvation condition (GenAge does not mention it)? Edit \ Update (Admin) | Delete |
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