Denigma: Factor

Nudt1

Symbol: Nudt1
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 1
Alias: Mth1
Entrez gene ID: 17766
Ensembl gene ID: ENSMUSG00000036639
Species: Mouse (Taxid: 10090)

Observation:

hMTH1-Tg mice express high levels of the hMTH1 hydrolase that degrades 8-oxoGTP and 8-oxoGTP and excludess 8-oxoguanine from both DNA and RNA.

hMTH1-overexpresing mice have significantly lower steady-state levels of 8-oxoguanine in both nuclear and mitochondrial DNA of several organs, including the brain. hMTH1 overexpression prevents the age-dependent accumulation of DNA 8-oxoguanine that occurs in the wild-type mice. These lower levels of oxidized guanines are associated with increased longevity and hMTH1-Tg animals live significantly longer than their wild-type littermates [23648059].

Interventions:

Nudt1 Overexpression

Assays: Organismal Lifespan

Classification:

Aging-Suppressor

Positive Aging-Suppressor

Type:

Gene

References:

23648059: Prolonged Lifespan with Enhanced Exploratory Behavior in Mice Overexpressing the Oxidized Nucleoside Triphosphatase hMTH1.

Aging Relevance Analysis/Source:

GenAge