Denigma: Factor

Jafrac1

Symbol: Jafrac1
Name: thioredoxin peroxidase 1
Entrez gene ID: 53578
Ensembl gene ID: FBgn0040309
Species: Fly (Taxid: 7227)

Observation:

Neuronal overexpression of Jafrac1 significantly increases both mean and maximum lifespan, while neuronal knockdown as well as loss of function mutation, causes a reduction in lifespan by 30%. The mean lifespan is 26% and 29% higher in females and males, respectively. The maximum lifespan is increased by 22% and 26% in females and males, respectively [19720829].

There is a consistent and significant lifespan extension (15% mean lifespan increase) in both males and females when Jafrac1 is overexpressed in somatic cells. Jafrac1 overexpression using the weaker 5961FS driver moderately but significantly extends lifespan [20976250].

Interventions:

Jafrac1 overexpression +15 to +29% +22 to +26%

Assays: Organismal Lifespan
Mean: +15 to +29
Maximum: +22 to +26

Classification:

Aging-Suppressor

Positive Aging-Suppressor

Type:

Gene

Protein coding

References:

19720829: JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span.

20976250: Lifespan extension by preserving proliferative homeostasis in Drosophila.

Aging Relevance Analysis/Source:

GenAge