EXO1

Symbol: EXO1
Name: exonuclease 1
Entrez gene ID: 9156
Ensembl gene ID: ENSG00000174371
Species: Human (Taxid: 9606)

Function:
DNA repair

Observation:

The rs1776180 C allele in the promoter of EXO1 is significantly enriched in female Germans centenarians and this can be replicated in 445 female French centenarians. The C allele leads to the loss of binding site for the basic helix-loop-helix transcription factor E47, resulting in higher EXO1 expression [19698732].EXO1 was found to be associated with longevity [19698732]. EXO1 was not found to be associated with longevity [23770741].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs1776180 0.01 [19698732]
  • rs1776180 0.16 [23770741]

  • Classification:
  • Aging Associated
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • Longevity-Associated
  • No Age Effect


  • References:
  • 19698732: A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • EXO1 (9606)
  • EXO1 (9598)
  • EXO1 (9615)
  • EXO1 (9913)
  • Exo1 (10090)
  • Exo1 (10116)
  • EXO1 (9031)
  • zgc:55521 (7955)
  • tos (7227)
  • AgaP_AGAP004491 (7165)

  • Inparanoids
  • ENSP00000355506 (9606)
  • ENSMUSP00000039376 (10090)
  • ENSRNOP00000005313 (10116)
  • ENSMMUP00000037489 (9544)
  • YOR033C (4932)
  • ENSP00000355506 (9606)



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