THC

Symbol: THC
Name: Tetrahydocurcumin
Entrez gene ID: 7454
Ensembl gene ID: ENSG00000015285
Species: Human
Function:
Tetrahydocurcumin (THC) is a curcumin metabolite.

Observation:

Tetrahydocurcumin extends the lifespan and reduces oxidative stress in male and female fruit flies. THC extends lifespan of Drosophila and inhibits the oxidative stress response by regulating FOXO and Sir2 [22156377].

In male mice supplementation with tetrahydrocurcumin beginning at the age of 13 month increases the mean lifespan by an average of 84 days, i.e. an increase of 11.7% [17516143].



Interventions:
  • THC treatment
  • THC treatment +11.7%

  • Assays: Organismal Lifespan

    Classification:
  • Gero-Suppressant


  • Type:
  • Drug

    References:
  • 22156377: Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor.
  • 17516143: The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • WAS (9606)
  • WAS (9615)
  • Was (10090)
  • wasb (7955)

  • Inparanoids
  • ENSMUSP00000033505 (10090)
  • ENSRNOP00000050978 (10116)
  • ENSMMUP00000025995 (9544)



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