egl-4

Symbol: egl-4
Name: EGg Laying defective
Entrez gene ID: 176991
Ensembl gene ID: F55A8.2
Species: Worm (Taxid: 6239)

Functional description:
Cyclic GMP-dependant protein kinase involved in multiple signaling pathway; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying and dauer formation. [UniProt]

Observation:

Mutations in egl-4 extends lifespan by up to 55%. Lifespan extension by mutation of egl-4 is suppressed by daf-16. egl-4 mutation results in normal morphology and development, however egl-4 animals are almost twice as big as normal and have weak eff-laying defects [12571101].



Interventions:
  • egl-4 mutation +55%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PRKG1 (9606)
  • PRKG1 (9598)
  • Prkg1 (10090)
  • LOC566430 (7955)
  • AgaP_AGAP008863 (7165)
  • egl-4 (6239)
  • PKG (5833)



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