Symbol: eft-2 Name: Elongation FacTor Entrez gene ID: 172743 Ensembl gene ID: F25H5.4 Species: Worm (Taxid: 6239) Functional description: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Involved in the morphogenesis of epidermal tissues. [UniProt] Observation: Post-developmental RNA interference reduces mean lifespan by 15% [17673661]. Knockdown of eft-2 started after the animal reached the late L4 stage increases mean lifespan by 6-27% and 8%, respectively [22103665]. Interventions: Assays: Organismal Lifespan Mean: -15 to +27 Maximum: +8 Classification: Aging Relevance Analysis/Source: Homologs Note: Discrepance! Edit \ Update (Admin) | Delete |
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