Denigma: Factor

frh-1

Symbol: frh-1
Name: FRataxin (involved in human Friedrich's ataxia) Homolog
Entrez gene ID: 174002
Species: Worm (Taxid: 6239)

Function:
mitochondrial protein

Observation:

Complete absence of frataxin,the mitochondrial protein defective in individuals with Friedreich ataxia is lethal, while its partial deficiency extends animal lifespan in a p53 dependent manner. Frataxin knockdown via RNAi extends mean and maximum lifespan by 19 and 37%, respectively [23247094].

Substantial reduction of frataxin protein expression is required to extend lifespan, affect sensory neurons functionality, remodel lipid metabolism and trigger autophagy. Beclin and p53 genes are required to induce autophagy and concurrently reduce lipid storages and extend animal lifespan in response to frataxin suppression. Frataxin expression modulates autophagy in the absence of p53 [23247094].

Interventions:

frh-1 RNAi +18.75% +37.037037037%

Assays: Organismal Lifespan
Mean: +18.75
Maximum: +37.037037037

Classification:

Gerontogene

Positive Gerontogene

References:

23247094: Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans.

Aging Relevance Analysis/Source:

GenAge