Denigma: Factor

Efemp1

Symbol: Efemp1
Name: Epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Entrez gene ID: 216616
Ensembl gene ID: ENSMUSG00000020467
Species: Mouse (Taxid: 10090)

Functional description:
Extracellular matrix (ECM) protein of unknown function; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (By similarity). [UniProt]

Observation:

Efemp1 knockout mice exhibited an early onset of aging-associated phenotypes including a 20% shorted median lifespan and 30% shorter maximum lifespan, decreased body mass, lordokyphosis, reduced hair growth, and atrophy [17872905].

Interventions:

Efemp1 knockout +20% +30%

Assays: Organismal Lifespan
Median: -20
Maximum: -30

Classification:

Aging-Suppressor

Negative Aging-Suppressor

References:

17872905: Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice.

Aging Relevance Analysis/Source:

GenAge