Denigma: Factor

EcR

Symbol: EcR
Name: Ecdysone receptor
Entrez gene ID: 35540
Ensembl gene ID: FBgn0000546
Species: Fly (Taxid: 7227)

Functional description:
Receptor for ecdysone. Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes. [UniProt]

Observation:

Mutant heterozygotes in EcR live on mean 40%-50% longer than controls [12610309; reviewed in 12610294]. Homozygous mutants in EcR are inviable. The developmental time and weight of EcR+/- mutants is the same as control, but resistance to temperature, oxidative stress, and starvation is increased in heterozygotes [12610309].

Interventions:

EcR mutation +40 to +50%

Assays: Organismal Lifespan
Mean: +40 to +50

Classification:

Gerontogene

Positive Gerontogene

Type:

Gene

Protein coding

References:

12610309: Steroid control of longevity in Drosophila melanogaster.

12610294: The endocrine regulation of aging by insulin-like signals.

Aging Relevance Analysis/Source:

GenAge