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Symbol: CSODM Name: Carboxyfullerene SOD mimetic Observation: Administration of a small-molecule synthetic enzyme superoxide dismutase mimetic to wild-type (i.e. non-transgenic; non-senescence accelerated) mice starting at middle age significantly extends lifespan and reduces age-associated oxidative stress and mitochondrial radical production. Treatment also improves performance on Morris water maze learning and memory task and therefore rescues age-related cognitive impairment [17079053]. Carboxyfullerene SOD mimetic is an antioxidant with mitochondrial activity and nervous system penetration capability [17079053]. Interventions: Assays: Organismal Lifespan Classification: References: Edit \ Update (Admin) | Delete |
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