Denigma: Factor

eat-6

Symbol: eat-6
Name: EATing: abnormal pharyngeal pumping
Entrez gene ID: 179796
Ensembl gene ID: B0365.3
Species: Worm (Taxid: 6239)

Functional description:
Protein EAT-6; EATing: abnormal pharyngeal pumping family member (eat-6) [Source:RefSeq peptide;Acc:NP_506269] [Ensembl]; eat-6 encodes an ortholog of the alpha subunit of a sodium/potassium ATPase, which in turn affects Na+,K(+)-ATPase activity of membranes by affecting the level of the phosphorylated intermediate of the Na+,K(+)-ATPase; EAT-6 affects relaxation of the pharyngeal muscles, fertility (and thus affects feeding); EAT-6 also affects body length, life span, and ASE, ASI and ASJ axonal outgrowth. [WormBase]

Observation:

Mutations in eat-6 extend lifespan by 15-40%. Lifespan extension is proposed to be similiar to DR [9789046]. eat-1 mutants have defects in haryngeal feeding behavior [8462849].

Interventions:

eat-6 mutation +15 to +40%

Assays: Organismal Lifespan

Classification:

Gerontogene

Positive Gerontogene

Aging Relevance Analysis/Source:

GenAge