Denigma: Factor

Dcr-2

Symbol: Dcr-2
Name: Dicer-2
Entrez gene ID: 36993
Ensembl gene ID: FBgn0034246
Species: Fly (Taxid: 7227)

Function:
Biogenesis of endogenous small interfering RNAs

Observation:

Median lifespan of homozyogous and transheterozyogous Dcr-2 mutants is reduced by 18-36% in males and by 27-36% in females. Dcr-2 loss changes the expression of mostly metabolic genes implicated in stress resistance and aging. Dcr-2 mutants are hypersensitive to oxidative, endoplasmic reticulum, starvation and cold stress as well as abnormal lipid and carbohydrate metabolism [21889502].

Interventions:

Dcr-2 mutation -18 to -36%

Assays: Organismal Lifespan
Mean: -18 to -36

Classification:

Aging-Suppressor

Negative Aging-Suppressor

References:

21889502: The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis.

Aging Relevance Analysis/Source:

GenAge