Denigma

alg-1

Symbol: alg-1
Name: Argonaute (plant)-Like Gene
Entrez gene ID: 181504
Species: Worm
Function:
Necessary for miRNA maturation and function

Observation:

Adult-specific knockdown of the C. elegans argonaute-like gene 1 alg-1 results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936].



Interventions:
  • alg-1 RNAi -9.6 to -16.1% -13.7%

    • Assays: Organismal Lifespan
    Mean: -9.6 to -16.1
    Maximum: -13.7

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • References:
  • 21810936: Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • EIF2C2 (9606)
  • EIF2C2 (9598)
  • EIF2C2 (9615)
  • EIF2C2 (9913)
  • Eif2c2 (10090)
  • Eif2c2 (10116)
  • LOC570630 (7955)
  • AGO1 (7227)
  • AgaP_AGAP011717 (7165)
  • alg-1 (6239)
  • alg-2 (6239)
  • AGO1 (3702)
  • Os02g0672200 (4530)



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