|
Symbol: VPH2 Name: Vacuolar pH 2 Alias: CLS10; VMA12 Entrez gene ID: 853741 Ensembl gene ID: YKL119C Species: Yeast (Taxid: 4932) Function: VPH2 is and endoplasmic-reticulum-localized integral membrane protein required for the assembly and therefore also activity of the vacuolar H+-ATPase (V-ATPase) [9325326]. Observation: Overexpression of VPH2 increases the levels of assembled V-ATPase at the vacuolar membrane, increases vacuolar acidity and suppresses age-induced mitochondrial dysfunction of aged cells (17 or 18 cell divisions) which requires the V-ATPase activity. VPH2 overexpression significantly increases mean, median and maximum replicative lifespan by 23, 25 and 34%, respectively [23172144]. Interventions: Assays: Replicative Lifespan Mean: +23.1 Median: +25.0 Maximum: +34.0 Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit