AVT1

Symbol: AVT1
Name: Amino acid Vacuolar Transport 1
Entrez gene ID: 853457
Ensembl gene ID: YJR001W
Species: Yeast (Taxid: 4932)

Function:
AVT1 is a a neutral amino acid transporter [11274162].

Observation:

Overexpressing or deleting AVT1 is sufficient to extend or shorten replicative lifespan, respectively [23172144].

Overexpression of AVT1 prevents mitochondrial dysfunction, prevents alterations in mitochondrial structure and ΔΨ of aged cells even through the vacuolar acidity is reduced in these cells. AVT1 overexpression extends the mean, median and maximum replicative lifespan by 28, 28, and 22%, respectively [23172144].

Deletion of AVT1 accelerates the development of age-induced mitochondrial dysfunction without effecting the kinetics of vacuolar acidity decline and prevents the suppression of mitochondrial dysfunction by VMA1 and VPH2 overexpression without affecting vacuolar acidity. AVT1 deletion decreases mean, median and maximum replicative lifespan by 21, 22, and 12%, respectively [23172144].



Interventions:
  • AVT1 deletion -20.6% -22.4% -11.8%
  • AVT1 overexpression +27.8% +27.6% +21.6%

  • Assays: Replicative Lifespan
    Mean: -20.6 to +27.8
    Median: -22.4 to +27.6
    Maximum: -11.8 to +21.6

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Positive Aging-Suppressor
  • DR-Essential


  • References:
  • 23172144: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • AVT1 (4932)
  • KLLA0D09779g (28985)
  • AGOS_ACR030W (33169)
  • GeneID:2679813 (148305)
  • NCU06231 (5141)



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