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Symbol: eat-1 Name: EATing: abnormal pharyngeal pumping Species: Worm (Taxid: 6239) Functional description: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity. [UniProt] Observation: Loss-of-function mutations in eat-1 extend lifespan byy 10-30%. Lifespan extension is proposed to be similar to DR [9789046]. eat-1 mutants have defects in pharyngeal feeding behavior [8462849]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRNote: Has no entrez gene id Edit \ Update (Admin) | Delete |
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