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Symbol: CG13890 Entrez gene ID: 38100 Ensembl gene ID: FBgn0035169 Species: Fly (Taxid: 7227) Function: CG13890 encodes the dodecenoyl-CoA delta-isomerase (DCI) localized in the inner mitochondria where it catalyses the degradation of long-chain fatty acids during fatty-acid β-oxidation [11916962; 20195903]. Observation: Overexpression of CG13890 (DCI) throughout the whole body increases mean and median lifespan by 35 and 31%, but decreases maximum lifespan by 6%, increases stress resistant (to paraquat and starvation), consistently reduces the mortality rate across adult ages and reduces the lifespan extension of DR by 15% [22997544]. CG6783 overexpression increases the dFOXO nuclear localization in the fat-body. mRNA levels of dFOXO target genes l(2)efl and 4E-BP in the adult whole bodies increases in response to overexpression of CG6783 [22997544]. Interventions: Assays: Organismal Lifespan Mean: +35 Median: +31 Maximum: -6 Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Note: Why does CG6783 overxpression decrease maximum lifespan? Edit \ Update (Admin) | Delete |
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