Overproduction of Fgf-21 increases mean lifespan of males by 30% and that of females by 39% [23066506].

Mice overproducing Fgf21 are lean throughout their lives and remain lean even while eating slightly more than wild-type mice. Fgf21 overproducers tend to be smaller than wild-type mice and female mice were infertile. Although Fgf21 overproducers have significantly lower bone density than wild-type, Fgf21-abundant mice exhibit no ill effects from the reduced bone density and remain active into old age without any broken bones.

Fgf21 seems to provide its health benefits by increasing insulin sensitivity and blocking the growth hormone/insulin-like growth factor-1 signaling.

Fgf21 acts as a hormone, is secreted by the liver during fasting and helps the body to adapt to starvation.

GenAge

GenDR