Symbol: Res Name: Resveratrol Observation: Resveratrol significantly extends the lifespan of yeast [12939617]. Resveratrol supplementation prolongs the lifespan of nematodes [15254550; 17460219], but not in any case [17875315]. In fruit flies supplementation with resveratrol extends the lifespan [15254550], but not in always [17875315]. In Nothobranchius furzeri a maximum dose of resveratrol increases the median lifespan by 56% [16461283]. Resveratrol conteracts the detrimental effects of a high-fat diet in mice an decreases the risk of death by 30% and thereby reverting it to the level of normal diet. It also partially corrected a subset of the abnormal gene expression profile and insulin as well as glucose metabolism [17086191]. Although resveratrol has range a of beneficial effects in elderly mice, it does not increase the longevity of ad libitum fed mice when started midlife [18599363]. Even at high doses and when started in young adulthood reseveratrol supplementation does not increase lifespan on a normal diet [17578509; 20974732]. Interventions: Assays: Organismal Lifespan Classification: Edit \ Update (Admin) | Delete |
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