Laz

Symbol: Laz
Name: Lazarillo
Species: Fly (Taxid: 7227)

Function:
Glycosyl-phosphatidylinositol (GPI)-linked glyocoprotein

Observation:

Extracellular forms of Laz have autocrine and paracrine protecting effects for oxidative stress-challanged Drosophila S2 cells. Local effects of GPI-linked Laz inside and outside the nervous system promote survival upon different stress forms, and extend lifespan and healthspan of the flies in a cell-type dependent manner. Ectopic enhancement of Laz expression increases mean, median, and maximum lifespan. Laz overexpression (via the use of a ubiquitous da-GAL4 driver) increases median lifepan by 28.3% (p < 0.0005). Overexpression of Laz specifically in muscles and brain (via GAL4109(2)80 driver) increases median lifespan by 43.5%. Laz overxpression in dopaminergic and serotenergic neurons and epidermis increases median lifespan bt 31.4% (p < 0.0005) [22846641].



Interventions:
  • Lazarillo supplementation +28.3 to +43.5%

  • Assays: Organismal Lifespan

    Classification:
  • Gero-Suppressant


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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