Symbol: TOMM40 Name: translocase of outer mitochondrial membrane 40 homolog (yeast) Alias: APOE; APOC1 Entrez gene ID: 10452 Ensembl gene ID: ENSG00000130204 Species: Human (Taxid: 9606) Function: Mitochondrial function; Channel-forming unit of mitochondrial outer membrane translocase Observation: TOMM440 correlates substantial with longevity and has been associated with Alzheimer's disease [22279548]. rs4420638 at TOMM40 gene locus exhibits significant association with longevity p-value = 9.6x10^-8). Combined modeling of linkage and association shows that association of longevity with APOEepsilon4 and APOEepsilon2 alleles explain the linkage at 19q1.11-q13.32 with pvalue-0.02 and p-value=1.0x10^-5, respectively [23286790]. TOMM40 was found to be associated with longevity [21418511; 23040522; 22279548]. TOMM40 was not found to be associated with longevity [24924924]. TOMM40 was found to be associated with longevity [24924924]. Assays: Organismal Lifespan Longevity Associated Variants: Classification: Type: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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