pck-1

Symbol: pck-1
Name: Phosphoenolpyruvate CarboxyKinase 1
Alias: PEPCK-1
Entrez gene ID: 175171
Ensembl gene ID: W05G11.6
Species: Worm (Taxid: 6239)

Function:
cytosolic form of phosphoenolpyruvate carboxykinase

Observation:

RNA interference of pck-1 during the adulthood significantly shortens lifespan of both wild-type and eat-2 mutants. RNAi knockdown of pck-1 from hatching cases larval lethality. Overexpression of pck-1 greatly increases content of PEPCK-C, markedly induces enzyme activity and significantly increases mean, 75%ile, and maximum lifespan by 19-23%, 17-22%, and 21% [22810224].



Interventions:
  • pck-1 RNAi
  • pck-1 overexpression +19 to +23% +21%

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PCK2 (9606)
  • PCK2 (9598)
  • PCK2 (9615)
  • PCK2 (9913)
  • Pck2 (10090)
  • Pck2 (10116)
  • pck2 (7955)
  • Pepck (7227)
  • AgaP_AGAP003350 (7165)
  • R11A5.4 (6239)
  • W05G11.6 (6239)



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