Symbol: MXR2 Name: peptide Methionine sulfoXide Reductase 2 Alias: MSRB; MsrB Entrez gene ID: 850324 Ensembl gene ID: YCL033C Species: Yeast (Taxid: 4932) Functional description: Although deletion of MsrA decreases and overexpression increases the life span by 25%, deletion or overexpression of MsrB has no effects under normal growth conditions. However, simultaneous deletion of both genes dramatically reduces the life span by 63% suggesting a role of MsrB in the absence of MsrA. Remarkably, overexpression of MsrB under calorie-restriction conditions extends life span by 120%. As opposed to the expected extension of life span, cells lived 35% shorter under anaerobic conditions and neither deletion nor overexpression of MsrA or MsrB had modulatory effects on the life span [Koc et al, 2004] Observation: Deletion or overexpression of MXR2 (alias MsrB) has no effect on replicative lifespan under normal growth conditions. Simulatonous deletion of MXR2 together with MXR1 dramatically reduces replicative lifespan by 63%. Overexpression of MXR2 under DR conditions extends replicative lifespan by 120% [15141092]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source: Homologs Note: According to SGD: lactate carbon source Details: lifespan extended (25% Edit \ Update (Admin) | Delete |
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