MXR2

Symbol: MXR2
Name: peptide Methionine sulfoXide Reductase 2
Alias: MSRB; MsrB
Entrez gene ID: 850324
Ensembl gene ID: YCL033C
Species: Yeast (Taxid: 4932)

Functional description:
Although deletion of MsrA decreases and overexpression increases the life span by 25%, deletion or overexpression of MsrB has no effects under normal growth conditions. However, simultaneous deletion of both genes dramatically reduces the life span by 63% suggesting a role of MsrB in the absence of MsrA. Remarkably, overexpression of MsrB under calorie-restriction conditions extends life span by 120%. As opposed to the expected extension of life span, cells lived 35% shorter under anaerobic conditions and neither deletion nor overexpression of MsrA or MsrB had modulatory effects on the life span [Koc et al, 2004]

Observation:

Deletion or overexpression of MXR2 (alias MsrB) has no effect on replicative lifespan under normal growth conditions. Simulatonous deletion of MXR2 together with MXR1 dramatically reduces replicative lifespan by 63%. Overexpression of MXR2 under DR conditions extends replicative lifespan by 120% [15141092].



Interventions:
  • MXR2 deletion
  • MXR2 overexpression

  • Assays: Replicative Lifespan

    Classification:
  • DR-Essential
  • No Age Effect


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SPBC216.04c (4896)
  • MXR2 (4932)
  • KLLA0C01342g (28985)
  • AGOS_AFR708W (33169)
  • GeneID:2681593 (148305)
  • NCU03891 (5141)
  • MSRB2 (3702)
  • Os05g0404200 (4530)

  • Note: According to SGD: lactate carbon source Details: lifespan extended (25%

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