Symbol: let-4 Name: LEThal 4 Alias: sym-5 Entrez gene ID: 181554 Ensembl gene ID: C44H4.2 Species: Worm (Taxid: 6239) Functional description: Protein LET-4; SYnthetic lethal with Mec family member (sym-5) [Source:RefSeq peptide;Acc:NP_510425] [Ensembl]; let-4 encodes an extracellular leucine-rich repeat only protein; let-4 was originally identified in a screen for essential genes, and let-4 mutants exhibit early larval lethality; let-4 is required for organization of the apical extracellular matrix, and is involved in excretory cell canal morphology and renal function as mutants exhibit excretory canal cysts and impaired renal function. [WormBase] Observation: let-4 (alias sym-5) is downregulated in space. RNA intereference of let-4 extends mean and 75%ile lifespan by 4%, but reduces maximum lifespan by 25% [22768380]. Interventions: Assays: Organismal Lifespan Classification: References: Aging Relevance Analysis/Source: Homologs Note: Effects mean and maximum lifespan in the opposite manner. Is it actually significant? Edit \ Update (Admin) | Delete |
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